Oxytocin Versus Misoprostol Plus Oxytocin in the Prevention of Postpartum Hemorrhage at a Semi-Urban Hospital in sub-Saharan Africa: A Retrospective Cohort Study
DOI:
https://doi.org/10.21106/ijma.365Keywords:
- Misoprostol,
- Oxytocin,
- Postpartum Hemorrhage,
- Cameroon
Abstract
Background: Post-partum hemorrhage (PPH) is a leading cause of maternal mortality. Its first-line of prevention often entails uterotonic drugs like oxytocin and misoprostol which constitute a core point of management in low-resource settings of sub-Saharan Africa. This study aimed to assess the effectiveness of oxytocin alone compared with oxytocin plus misoprostol in two different eras (before and after the advert of misoprostol) of a semi-urban Cameroonian hospital.
Methods: This was a retrospective cohort study carried out between January 2015 to April 2015 and between January 2016 to April 2016 on a group of parturients (group A) who received only oxytocin and another administered oxytocin and misoprostol (group B), respectively. All participants delivered at the Bamenda Regional Hospital, Cameroon. The two different periods represent the era before and after the implementation of misoprostol in the prevention of PPH in this semi-urban hospital. Socio-demographic data, clinical characteristics and details of delivery as well as risk factors for PPH were studied from obstetric records.
Results: We studied the obstetric records of 1778 parturients were studied; 857 in group A and 879 in group B. Their mean age was 26.3 ±5.2 years. Both groups were comparable in several baseline sociodemographic and clinical characteristics. The prevalence of PPH was 2.7% (3.4% vs 2.2%; p = 0.0744). The risk of PPH in the oxytocin only group was about 1.5 times higher than in the oxytocin plus misoprostol group. The estimated blood loss between the two groups was statistically significant (1100 ± 150 vs 800 ± 100 ml, p< 0.0001). The active management of the third stage of labor without misoprostol was the only risk factor for PPH.
Conclusion and Global Health Implications: The implementation of misoprostol plus oxytocin in the prevention of PPH in this low-resource setting improved the obstetrical outcome by reducing the risk and the amount of blood loss during delivery.
Downloads
Similar Articles
- Elizabeth Armstrong, Priya Srinivasan, Dawood Azeemy, Fayja Habib, Ernest Alema-Mensah, COVID-19 Stressors and Maternal Mental Health in Georgia, United States: Sources, Effects, and Recommendations , Vol. 14 No. Continuous (2025): International Journal of Maternal and Child Health and AIDS
- Kimberly Fryer, Chinyere N. Reid, Naciely Cabral, Jennifer Marshall, Usha Menon, Exploring Patients’ Needs and Desires for Quality Prenatal Care in Florida, United States , Vol. 12 No. 1 (2023): International Journal of Maternal and Child Health and AIDS
- Musawenkosi H L Mabaso, Thoko Ndaba, Zilungile L Mkhize-Kwitshana, Overview of Maternal, Neonatal and Child Deaths in South Africa: Challenges, Opportunities, Progress and Future Prospects , Vol. 2 No. 2 (2014): International Journal of Maternal and Child Health and AIDS
- Kolawole A. Fasakin, Christopher T. Omisakin, Idowu O. Adebara, Wasiu A. Ajetunmobi, Adebayo A. Adeniyi, Ayodele J. Esan, Olufunke B. Bolaji, Oluwafemi D. Ajayi, Abayomi J. Afe, Assessment of PMTCT Success Rates Based on Antiretroviral Interventions and Feeding Options: A Prospective Cohort Study , Vol. 7 No. 2 (2018): International Journal of Maternal and Child Health and AIDS
- Frankline Sevidzem Wirsiy, Claude Ngwayu Nkfusai, Denis Ebot Ako-Arrey, Esther Kenfack Dongmo, Florence Titu Manjong, Samuel Nambile Cumber, Acceptability of COVID-19 Vaccine in Africa , Vol. 10 No. 1 (2021): International Journal of Maternal and Child Health and AIDS
- Margaret Omowaleola Akinwaare, Funmilayo A. Okanlawon, Monisola A. Popoola, Omotayo O. Adetunji, Birth Preparedness Plans and Status Disclosure Among Pregnant Women Living with HIV Who are Receiving Antiretroviral Therapy in Ibadan, Southwest, Nigeria , Vol. 12 No. 1 (2023): International Journal of Maternal and Child Health and AIDS
- Alana F. Hairston, Emily A. Bobrow, Christian S. Pitter, Towards the Elimination of Pediatric HIV: Enhancing Maternal, Sexual, and Reproductive Health Services , Vol. 1 No. 1 (2012): International Journal of Maternal and Child Health and AIDS
- Smitha Kochukuttan, TK Sundari Ravindran, Suneeta Krishnan, Evaluating Birth Preparedness and Pregnancy Complications Readiness Knowledge and Skills of Accredited Social Health Activists in India , Vol. 2 No. 1 (2013): International Journal of Maternal and Child Health and AIDS
- Anays Murillo, Mary Bachman DeSilva, Lora L. Sabin, Nafisa Halim, Harriet Chemusto, Philip Aroda, Julia Gasuza, Davidson H. Hamer, Anna Larson Williams, Barbara Mukasa, Lisa J. Messersmith, Rachael Bonawitz, Impact of a Maternal Prevention of Mother-to-child Transmission of HIV (PMTCT) Intervention on HIV-exposed Infants in Uganda , Vol. 9 No. 3 (2020): International Journal of Maternal and Child Health and AIDS
- Gopal K. Singh, Hyunjung Lee, Trends and Racial/Ethnic, Socioeconomic, and Geographic Disparities in Maternal Mortality from Indirect Obstetric Causes in the United States, 1999-2017 , Vol. 10 No. 1 (2021): International Journal of Maternal and Child Health and AIDS
<< < 2 3 4 5 6 7 8 9 10 11 > >>
You may also start an advanced similarity search for this article.
Published
How to Cite
Issue
Section
License
Copyright © 2020 Emmanuel Numfor, Nkengafac Nyiawung Fobellah, Joel Noutakdie Tochie, Tsi Njim, Sylvester Atanga Ndesso. Published by Global Health and Education Projects, Inc., USA.
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License , which permits others to remix, transform, and build upon the work non-commercially, provided the original author is credited and the new creations are licensed under the same terms.